One widely known popular theory is the homogenization as a probable cause of current and epic heart disease. The hypothesis as well as the study was developed and connected by Dr. Kurt A. Oster on early 1960s and it was ended in mid 1980s. In general, the research aimed at study and compare the biochemistry and structure of diseased and healthy arterial tissue. He also investigated plasmalogen, which is an essential and fatty component of most cell membranes that is broadly scattered in the tissues all over the human body. In addition, this plasmalogen is one of the important membrane parts that surround the heart muscle cells as well as the cells that are found in the walls of the arteries. It is also noted in the myelin sheath, which basically surrounds the nerve fibers. Moreover, it is observed as well in many other tissues.

Dr. Osters found out that artery tissue and heart cells must contain plasmalogen. However, in atherosclerosis, it most often contains no plasmalogen. With this, he thought of the reason why plasmalogen is lacking in the body. He believed that enzyme xanthine oxidase has sufficient capacity to change and oxidize plasmalogen into different substances. With this, it appears that plasmalogen is missing or had disappeared.

In general, milk from the cow is a food that contains high levels and amounts of XO. According to him, XO that did not undergo pasteurization or did not processed by homogenizer is easily broken down and absorbed during digestion. From this, he concluded that XO passing through a homogenizer reduces more of the fat globule sizes. Also, through homogenization, XO becomes encapsulated with new outer membranes. So, if new membrane protectors XO, it can not be digested by digestive enzymes. This then allows some XO to pass within fat globules. It then traversed the whole gut in order to reach a circulatory system. After reaching the circulation, it travels along the capillaries. In this area, lipoprotein is being digested and broken down by enzyme lipoprotein lipase. This step allows the XO to be free and be absorbed in the body. It then strengthens the artery tissues and destroys plasmalogen.

In essence, the theory of Dr. Oster replaces cholesterol as the main cause of suffering from heart disease. Instead, he gives some mechanisms that explain the real heart disease mechanism.

Homogenizer can lead to the production of noxious enzyme which is commonly known as xanthine oxidase. This is encapsulated in the liposome and can easily be absorbed into the circulation. It is basically released through an enzymatic action and it ends up inside arteries and heart tissue. Inside arterial and heart tissue, XO causes the destruction of plasmalogen, a specialized lipid that protects the membrane. This substance is also the main cause of lesions of the treaties that will later result in plaque development, which leads to heart disease. With XO, plasmalogen is being destroyed completely. With this, the chance and development of atherosclerotic plaque are greatly reduced leading to a decreed risk of suffering heart diseases.